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The industry is highly concentrated: in 2024 Novo Nordisk had ~59% of revenue ($31.75B) and Eli Lilly ~41% ($21.72B) ( [25] ), reflecting dominance of weekly semaglutide and dulaglutide, with Lillys tirzepatide rapidly rising

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To quantify the proportion of M2 macrophages, cells were stained with APC anti-mouse CD206 antibodies (BioLegend, USA) and PE-Cy7 anti-mouse CD86 antibodies (BD, Cat No